There’s something utterly indulgent about creamy, cheesy pasta baked to perfection, and my Creamy Chicken Alfredo Lasagna Roll-Ups Recipe hits all those cozy notes. It’s a comforting dish that’s both elegant and surprisingly simple to make—a real crowd-pleaser every time.

A close-up of a rolled lasagna slice held by a wooden spoon, showing three visible layers of wavy pale yellow pasta with a creamy white cheese sauce filling that looks smooth and thick. The top layer is slightly browned and bubbly, sprinkled with small green herb pieces. Thin strings of melted cheese pull away from the lasagna, giving a stretchy texture impression. The background shows more lasagna with a creamy color, all set on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Jump to:

Why You'll Love This Recipe
Ingredients & Why They Work
Make It Your Way
Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Top Tip
How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe
Make Ahead and Storage
Frequently Asked Questions:
Final Thoughts
Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Why You'll Love This Recipe

I’m genuinely excited to share this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe because it feels indulgent without being complicated. Every bite is velvety, cheesy, and packed with flavor, making it a perfect weeknight dinner or a special occasion treat.

Effortless Comfort Food: The recipe combines familiar flavors in a new, fun form that’s easier to portion and serve than traditional lasagna.
Rich, Creamy Sauce: The homemade Alfredo sauce is thick, flavorful, and so satisfying—definitely a game-changer compared to jarred sauces.
Customizable & Family-Friendly: You can swap chicken for veggies or add your favorite herbs, making it adaptable for different tastes.
Make-Ahead Friendly: These roll-ups freeze beautifully, so you can prep in advance for busy nights.

A white rectangular baking dish holds a baked lasagna with three visible layers. The bottom layer shows creamy white sauce with bits of light yellow pasta sheets. The middle layer has a mix of pale yellow pasta sheets interspersed with small pieces of light-colored filling. The top layer is covered with melted cheese, mostly golden brown with some slightly darker spots, sprinkled with small bits of green herbs. The edges of the pasta are soft and slightly ruffled. The dish rests on a white marbled surface. photo taken with an iphone --ar 2:3 --v 7

Ingredients & Why They Work

This recipe leans on classic ingredients that play off each other perfectly—the creamy Alfredo base pairs beautifully with tender chicken and gooey mozzarella. Here are some tips on getting the best out of each ingredient before you start.

Flat lay of uncooked flat, wide lasagna noodles neatly stacked, a few whole uncracked brown eggs, a small pat of golden butter, three fresh garlic cloves with papery skins, a small mound of fine all-purpose flour on a white ceramic plate, a small white bowl filled with creamy whole milk, another small white bowl with thick heavy whipping cream, a small white bowl with finely grated parmesan cheese, a small white bowl holding ground black pepper powder, a small white bowl with ground nutmeg powder, a pile of cooked shredded white chicken breast, a pile of shredded mozzarella cheese, and a few sprigs of bright green fresh parsley all arranged symmetrically with perfect balance on a clean white marble surface, soft natural light, photo taken with an iPhone, professional food photography style, fresh ingredients, white ceramic bowls, no bottles, no duplicates, no utensils, no packaging --ar 2:3 --v 7 --p m7354615311229779997

Lasagna noodles: Choose no-boil noodles if you want a shortcut, but I prefer regular noodles cooked al dente so they’re pliable enough to roll without cracking.
Butter: Use unsalted to control the saltiness of your sauce.
Garlic: Fresh cloves offer a fragrant depth that garlic powder can’t match.
All-purpose flour: This helps thicken the Alfredo sauce to that perfect creamy consistency.
Milk and heavy cream: Combining both gives the sauce richness without being too heavy.
Parmesan cheese: Freshly grated is best—you’ll notice the flavor difference immediately.
Cooked shredded chicken: Leftover rotisserie chicken works wonders here and saves time.
Mozzarella cheese: Adds gooey meltiness and a lovely golden top when baked.
Fresh parsley: A sprinkle at the end brightens the dish visually and flavor-wise.

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Note: You'll find the complete list of ingredients, along with their exact measurements, in the printable recipe card at the bottom of this post.

Make It Your Way

While I love the classic version, I often tweak this Creamy Chicken Alfredo Lasagna Roll-Ups Recipe to suit whatever I have on hand or my mood—after all, great cooking is all about making the recipe fit you.

Variation: Sometimes, I swap the chicken for sautéed mushrooms and spinach for a vegetarian twist that still feels hearty and comforting.
Lower Fat Option: Using half-and-half instead of heavy cream lightens things up without losing too much creaminess.
Spice it Up: A pinch of red pepper flakes mixed into the sauce gives a nice subtle kick that I personally adore.
Cheese Swap: Try mixing mozzarella with provolone or fontina for extra gooeyness and flavor depth.

Step-by-Step: How I Make Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Step 1: Cook noodles to just al dente perfectly

Start by boiling your lasagna noodles in salted water. I like to cook mine just until al dente, meaning they’re tender but still firm enough to roll. Once drained, I keep them in the pot covered with room temperature water. This trick prevents them from sticking and keeps them pliable—trust me, it makes rolling so much easier!

Step 2: Make that silky Alfredo sauce

Melt butter over medium heat, then sauté minced garlic until you can smell that wonderful aroma (about 1 minute). Stir in flour and cook for another minute to form a roux; this thickens your sauce without lumps. Slowly whisk in the milk and cream, letting it simmer gently for 2 minutes. Then fold in freshly grated Parmesan, salt, pepper, and a hint of nutmeg if you want a slightly warm spice note. Keep whisking until it thickens up beautifully—if it gets too thick, add a splash more milk. The creaminess here is the heart of the whole recipe.

Step 3: Assemble your cheesy roll-ups

Spoon about half a cup of the Alfredo sauce onto the bottom of your greased baking dish—that layer keeps the roll-ups from sticking and adds moisture during baking. In a mixing bowl, combine 1 cup of the sauce with the shredded chicken and 1 cup of mozzarella cheese, seasoning if needed. Now, lay a single noodle flat and spread a thin layer of your chicken-cheese mixture evenly over it, then carefully roll it up. Repeat with remaining noodles until you have a dozen roll-ups ready to nestle into the dish.

Step 4: Bake until bubbly and golden

Cover the roll-ups with the remaining Alfredo sauce, sprinkle the last cup of mozzarella over the top, and bake at 375°F (190°C) for about 25-30 minutes. You’ll know it’s ready when the cheese is melted, bubbling, and golden brown on top. For an extra crisp finish, I sometimes pop it under the broiler for a minute or two—just watch it closely so it doesn’t burn!

Top Tip

Over the years, I’ve learned that the secret to perfectly creamy but not watery Alfredo sauce is patience and gentle heat—rushing or cranking the heat can cause separation or lumps. Here are some tricks I rely on that you might find helpful:

Roux Foundation: Cook the butter and flour well before adding liquid—this builds a smooth base for your sauce.
Gradual Liquid Addition: Add milk and cream slowly while whisking so the sauce remains silky.
Cheese Temperature: Add Parmesan off the heat or on very low to avoid graininess.
Don’t Skip the Nutmeg: Just a pinch adds warmth and sophistication to the flavor.

How to Serve Creamy Chicken Alfredo Lasagna Roll-Ups Recipe

Chicken Alfredo Lasagna - Serving Suggestion

Garnishes

I love finishing these roll-ups with a sprinkle of freshly chopped parsley—it adds a pop of color and a fresh, mild herb flavor that balances the richness. Sometimes I also add a touch of cracked black pepper on top for a little bite.

Side Dishes

To keep things balanced, I often serve this creamy pasta alongside a crisp Caesar or mixed green salad. Garlic bread or roasted vegetables like asparagus or broccoli also complement the indulgence beautifully without overpowering it.

Creative Ways to Present

For dinner parties or holidays, I arrange the roll-ups neatly in a large oval dish and garnish with extra Parmesan and thyme sprigs. Another fun idea is using mini ramekins to make individual portions that feel special and prevent anyone fighting over the last piece!

Make Ahead and Storage

Storing Leftovers

Leftover roll-ups store beautifully in an airtight container in the fridge for up to 3 days. When I have extras, I make sure they’re fully cooled before covering tightly, which helps keep the texture just right.

Freezing

This recipe freezes like a dream. I prepare the roll-ups as usual, place them in a freezer-safe dish, cover tightly with foil, and freeze for up to 2 months. When I’m ready, I bake them covered at 375°F, adding extra time to ensure they’re heated through evenly.

Reheating

To reheat, I pop my leftovers in the oven at 350°F with foil loosely covering the dish, which keeps the sauce creamy and prevents the noodles from drying out. Microwave works too for a quick single portion—just cover the plate to trap steam.

Frequently Asked Questions:

Can I use store-bought Alfredo sauce for this recipe?

You can, but making homemade Alfredo sauce is easy and really elevates the dish’s flavor and texture. Store-bought sauces often have preservatives and can be thinner or overly salty, so homemade gives you full control.

How do I prevent the noodles from sticking when rolling?

Cooking the noodles until just al dente and then keeping them in a pot of room temperature water prevents them from sticking while you assemble. Also, work on a clean, lightly oiled surface when spreading the filling.

Can I make this recipe vegetarian?

Absolutely! You can replace the shredded chicken with sautéed mushrooms, spinach, or roasted vegetables. For added protein, consider adding ricotta or cottage cheese inside the rolls.

What’s the best way to reheat leftovers?

The best way is to cover the roll-ups with foil and warm them in the oven at 350°F until heated through—this keeps the sauce creamy and the noodles tender. The microwave works for quick reheating but can sometimes dry out the noodles.

Final Thoughts

This Creamy Chicken Alfredo Lasagna Roll-Ups Recipe is one of those dishes I keep coming back to whenever I want to impress without stress. It's rich, cozy, and feels really special, yet is surprisingly simple to pull off. Give it a try—you might find it becomes your new go-to comfort meal like it did for me!